Case study: The link between severe traumatic brain injury and coagulopathy

Carrick, M.M., Tyroch, A.H., Youmens, C.A., & Handley, T. (2005). Subsequent development of thrombocytopenia and coagulopathy in moderate and severe head injury: Support for

serial laboratory examination. The Journal of Trauma, Injury, Infection, and Critical Care, 58, 725–730.

Cohen, M.J., Brohi, K., Ganter, M.T., Manley, G.T., Mackersie, R.C., Pittet, J.F. (2007). Early coagulopathy after traumatic brain injury: The role of hypoperfusion and the protein C pathway. The Journal of Trauma, Injury, Infection, and Critical Care, 63, 1254–1262.

Kushimoto, S., Yamamoto, Y., Shibata, Y., Sato, H., & Koido, Y. (2001). Implications of excessive fibrinolysis and alpha-2-plasmin inhibitor deficiency in patients with severe head injury. Neurosurgery, 49, 1084–1090.

Martini, W.Z. (2009). Coagulopathy by hypothermia and acidosis: Mechanisms of thrombin generation and fibrinogen availability. The Journal of Trauma, Injury, Infection, and Critical Care, 67, 202–209.

Miner, M.E., Kaufman, H.H., Graham, S.H., Haar, F.H., & Gildenberg, P.L. (1982). Disseminated intravascular coagulation fibrinolytic syndrome following head injury in children: Frequency and prognostic implications. Journal of Pediatrics, 100, 687–691.

Olson, J.D., Kaufman, H.H., Moake, J., O’Gorman, T.W., Hoots, K., Wagner, K., Brown, K.C., & Gildenberg, P.L. (1989). The incidence of hemostatic abnormalities in patients with head injuries. Neurosurgery, 24, 825–832.

Stein, D.M., Dutton, R.P., Kramer, M.E., & Scalea, T.M. (2009). Reversal of coagulopathy in critically ill patients with traumatic brain injury: Recombinant Factor V11a is more cost effective than plasma. The Journal of Trauma, Injury, Infection, and Critical Care, 66(1), 63–75.

Talving, P., Benfield, R., Hadjizacharia, P., Inaba, K., Chan, L., & Demetriades, D. (2009). Coagulopathy in severe traumatic brain injury: A prospective study. The Journal of Trauma, Injury, Infection, and Critical Care, 66(1), 55–62.